YAG Laser And Microdermabrasion
5-aminolaevulinic acid (ALA) is used as a protoporphyrin IX-precursor for the photodynamic therapy of superficial skin cancer and cutaneous metastases of internal malignancies. However, the permeability of hydrophilic ALA across the skin is very low.
OBJECTIVES AND METHODS:
The objective of this study was to optimize and enhance the in vitro skin permeation of ALA by two resurfacing techniques: erbium:yttrium-aluminium-garnet (Erb:YAG) laser and . Light microscopic changes in pig skin caused by these techniques were also compared.
The electrically assisted methods, iontophoresis and electroporation, were also used to facilitate ALA permeation across laser- or -treated skin.
RESULTS:
Among the modalities tested in this study the Erb:YAG laser showed the greatest enhancement of ALA permeation. The laser fluence was found to play an important role in controlling the drug flux, producing enhancement ratios from 4-fold to 246-fold relative to the control.
The skin permeation of ALA across -treated skin was approximately 5-15-fold higher than that across intact skin. Both the ablated effect of the stratum corneum (SC) and ALA flux were proportional to the treatment duration of .
The application of iontophoresis or electroporation alone also increased the ALA permeation by approximately 15-fold and 2-fold, respectively. The incorporation of iontophoresis or electroporation with the resurfacing techniques caused a profound synergistic effect on ALA permeation.
CONCLUSIONS:
This basic study has encouraged the further investigation of ALA permeation by laser or .
"Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and : a comparison with iontophoresis and electroporation"
Fang JY, Lee WR, Shen SC, Fang YP, Hu CH
Br J Dermatol. 2004 Jul ; 151(1): 132-40 (Hubmed.org)
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