Lasers and microdermabrasion enhance and control topical delivery of vitamin C
The objective of this study was to evaluate the ability of lasers and , both of which are skin resurfacing modalities, to enhance and control the in vitro skin permeation and deposition of vitamin C.
The topical delivery of magnesium ascorbyl phosphate, the pro-drug of vitamin C, was also examined in this study. All resurfacing techniques evaluated produced significant increases in the topical delivery of vitamin C across and/or into the skin.
The erbium:yttrium-aluminum-garnet (Er:YAG) laser showed the greatest enhancement of skin permeation of vitamin C among the modalities tested. The laser fluence and spot size were found to play important parts in controlling drug absorption.
An excellent correlation was observed in the Er:YAG laser fluence and transepidermal water loss, which is an estimation of skin disruption.
Permeation of magnesium ascorbyl phosphate was not enhanced by the Er:YAG laser. The CO2 laser at a lower fluence promoted vitamin C permeation with no ablation of the stratum corneum or epidermal layers.
Further enhancement was observed with the CO2 laser at higher fluences, which was accompanied by a prominent ablation effect. ablated the stratum corneum layers with minimal disruption of the skin barrier properties according to transepidermal water loss levels.
The flux and skin deposition of vitamin C across -treated skin was approximately 20-fold higher than that across intact skin. The techniques used in this study may be useful for basic and clinical investigations of enhancement of topical vitamin C delivery.
"Lasers and enhance and control topical delivery of vitamin C"
Lee WR, Shen SC, Kuo-Hsien W, Hu CH, Fang JY
J Invest Dermatol. 2003 Nov ; 121(5): 1118-25 (Hubmed.org)
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