A randomized investigator-blind trial of different passes of microdermabrasion therapy and their effects on skin biophysical characteristics

Microdermabrasion (MDA) is a safe, simple, and beneficial technique for superficial skin resurfacing. Despite its popular usage, few studies have assessed the efficacy of different Microdermabrasion protocols applied at the present time.

Objectives To assess the effects of Microdermabrasion generally, as well as to compare the effects of two vs. three passes of Microdermabrasion (MDA) in each session for a total number of six therapeutic sessions on skin biophysical characteristics.

METHODS:
In this randomized, investigator-blind, split-face study, 10 patients underwent a series of six Microdermabrasion treatments with an interval of 2 weeks.

One side of the face was treated with two passes of Microdermabrasion and the other side was treated with three passes, randomly. Stratum corneum hydration, sebum secretion, and skin pH measurements were obtained before and after the procedure on all sessions and also 1 and 4 weeks after the last treatment.

RESULTS:
After six sessions of Microdermabrasion, a decrease in sebum content compared to baseline was shown at the end of treatment sessions, but no statistical difference was observed between two vs. three passes groups (-30.0 [interquartile range, IQR = 50.0] vs. -27.5 [IQR = 125.3], respectively, P = 0.58).

Comparison of two treatment groups showed significant higher values of sebum content in the first follow-up after treatment with three passes of Microdermabrasion. (64.0 [IQR = 52.0] for three passes vs. 45.0 [IQR = 46.0] for two passes, P = 0.04) A significant increase was observed in pH values at the end of treatment series, first and second follow-up after treatment with two passes of Microdermabrasion.

CONCLUSIONS:
MDA may have remarkable effects on skin barrier function changes resulting in skin clinical improvements (Cochrane Skin Group identifier: CSG No. 37).

"A randomized investigator-blind trial of different passes of microdermabrasion therapy and their effects on skin biophysical characteristics"
Davari P, Gorouhi F, Jafarian S, Dowlati Y, Firooz A
Int J Dermatol. 2008 May ; 47(5): 508-13 (Hubmed.org)



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