Microdermabrasion: A Molecular Analysis Following A Single Treatment

Microdermabrasion is a popular method of superficial skin resurfacing. It is unclear if dermal remodeling actually occurs.

OBJECTIVE:
To rigorously investigate the molecular alterations observed following a single microdermabrasion treatment.

METHODS:
Forty-nine subjects received a single microdermabrasion treatment to buttock skin. Serial in vivo biochemical and immunohistological analyses were performed.

Reverse transcriptase real-time polymerase chain reaction and immunohistochemistry assays were used to evaluate changes in transcription factors (AP-1, NF-kappaB), primary cytokines (interleukin-1beta, tumor necrosis factor-alpha), matrix metalloproteinases (MMP-1, MMP-3, MMP-9), barrier repair enzymes (acetyl-coenzyme A carboxylase, 3-hydroxy-3-methylglutaryl coenzyme A reductase), and type I procollagen.

Results Elevation of transcription factors, primary cytokines, and matrix metalloproteinases occurs rapidly after a single microdermabrasion treatment. Two of 11 subjects also demonstrated increased type I procollagen messenger RNA and protein levels 14 days after treatment. No alteration in stratum corneum thickness was detected.

CONCLUSION:
Microdermabrasion activates a dermal remodeling/wound healing cascade with minimal epidermal disruption. Evidence now exists to further study manipulation of variables such as number and timing of microdermabrasion sessions


"Microdermabrasion: a molecular analysis following a single treatment.
Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, Voorhees JJ, Fisher G
J Am Acad Dermatol. 2005 Feb ; 52(2): 215-23 (Hubmed.org)


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