Telomere-mediated effects on melanogenesis and skin aging.

J Investig Dermatol Symp Proc. 2009 Aug; 14(1): 25-31Gilchrest BA, Eller MS, Yaar MUV-induced melanogenesis (tanning) and "premature aging" or photoaging result in large part from DNA damage. This article reviews data tying both phenomena to telomere-based DNA damage signaling and develops a conceptual framework in which both responses may be understood as cancer-avoidance protective mechanisms.Journal of Investigative Dermatology Symposium Proceedings (2009) 14, 25-31; doi:10.1038/jidsymp.2009.9.