Reflex vasoconstriction in aged human skin increasingly relies on rho-kinase dependent mechanisms during whole-body cooling.

Primary human aging may be associated with augmented Rho-kinase (ROCK)-mediated contraction of vascular smooth muscle and ROCK-mediated inhibition of nitric oxide synthase (NOS). We hypothesized that the contribution of ROCK to reflex vasoconstriction (VC) is greater in aged skin.

Cutaneous VC was elicited by 1) whole-body cooling (Tsk=30.5 degrees C) and 2) local norepinephrine (NE) infusion (1x10(-6)M). Four microdialysis fibers were placed in the forearm skin of 8 young (Y) and 8 older (O) subjects for infusion of 1) Ringers solution (control), 2) 3 mM fasudil (ROCK inhibition), 3) 20 mM L-NAME (NOS inhibition), and 4) both ROCK + NOS inhibitors.

Red cell flux was measured by laser Doppler flowmetry (LDF) over each site. Cutaneous vascular conductance was calculated (CVC = LDF/MAP) and normalized to baseline CVC (%DeltaCVCbaseline). VC was reduced at the control site in O during cooling (Y: -34 +/- 3, O: -18 +/- 3 %DeltaCVCbaseline; P



"Reflex vasoconstriction in aged human skin increasingly relies on rho-kinase dependent mechanisms during whole-body cooling"
Am J Physiol Heart Circ Physiol. 2009 Aug 28; Lang JA, Jennings JD, Holowatz LA, Kenney WL (Hubmed.org)



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